UPSC-CMS 2020 — Pathology

Q: Common trisomies resulting in spontaneous abortion are all EXCEPT:

Trisomy 1. ***Trisomy 1*** - **Trisomy 1** is considered **lethal** and results in very early embryonic demise, often before a pregnancy is recognized, making it an extremely rare finding in spontaneous abortions. - The presence of an extra copy of such a large, gene-rich chromosome is **incompatible with early development**. *Trisomy 21* - **Trisomy 21 (Down syndrome)** is the most common autosomal trisomy that can result in a live birth, but it is also a frequent cause of **spontaneous abortion**. - While many pregnancies with Trisomy 21 result in live births, a significant proportion (approximately **75-80%**) end in miscarriage. *Trisomy 18* - **Trisomy 18 (Edwards syndrome)** is a common trisomy found in spontaneous abortions, second only to Trisomy 16. - While it can result in live births, the majority of fetuses with Trisomy 18 **miscarry spontaneously**. *Trisomy 16* - **Trisomy 16** is the most common trisomy identified in early spontaneous abortions, accounting for a large percentage of all chromosomal abnormalities leading to miscarriage. - It is considered **lethal** and is almost exclusively found in miscarried fetuses, with very rare exceptions of mosaic forms. [Practice more Pathology PYQs on OnCourse]

2 Previous Year Questions with Answers & Explanations

Questions

All Subjects Anatomy (3)Anesthesiology (1)Biochemistry (1)Community Medicine (34)Dermatology (1)Forensic Medicine (2)Internal Medicine (10)Microbiology (3)Obstetrics and Gynecology (32)Orthopaedics (4)Pathology (2)Pharmacology (3)Radiology (2)Surgery (21)

All of the following are major subtypes of breast cancer based on Gene array analysis EXCEPT:

Common trisomies resulting in spontaneous abortion are all EXCEPT: