NEET-PG 2015 Practice Questions

Q: Which of the following drugs is an alpha 2 agonist?

Apraclonidine. ***Apraclonidine*** - **Apraclonidine** is a synthetic **alpha-2 adrenergic agonist** that reduces aqueous humor production and increases uveoscleral outflow, thereby lowering intraocular pressure. - It is primarily used for the short-term treatment of **open-angle glaucoma** or ocular hypertension. *Timolol* - **Timolol** is a **non-selective beta-adrenergic blocker** that reduces aqueous humor production, leading to a decrease in intraocular pressure. - It does not act on alpha-2 receptors, distinguishing it from apraclonidine. *PG analogues* - **Prostaglandin analogues** (PG analogues) such as latanoprost, bimatoprost, and travoprost are primarily used to treat glaucoma by **increasing uveoscleral outflow** of aqueous humor. - They act on **prostaglandin F2α receptors**, not alpha-2 adrenergic receptors. *Verapamil* - **Verapamil** is a **calcium channel blocker** primarily used to treat hypertension, angina, and arrhythmias. - It acts by blocking calcium channels in vascular smooth muscle and the heart, and does not have significant alpha-2 adrenergic agonist activity.

Q: Which of the following is not typically associated with dementia?

Alteration of consciousness. ***Alteration of consciousness*** - An **alteration of consciousness** is a hallmark feature of **delirium**, which is an acute confusional state, usually fluctuating. - **Dementia** is primarily characterized by a chronic, progressive decline in cognitive function with **clear consciousness**. *Forgetfulness* - **Forgetfulness**, particularly memory loss impacting daily life, is one of the **earliest and most common symptoms** of dementia. - This symptom progressively worsens, affecting short-term and eventually long-term memory. *Reduced personal care* - As dementia progresses, individuals often experience a decline in their ability to perform **activities of daily living (ADLs)**, including personal care. - This can manifest as forgetting to bathe, difficulty dressing, or neglecting personal hygiene due to cognitive impairment. *Loss of neurons in brain* - **Neurodegeneration**, characterized by the **loss of neurons** and synapses in the brain, is the underlying pathological basis of most types of dementia, such as Alzheimer's disease. - This neuronal loss leads to brain atrophy and the cognitive deficits seen in dementia.

Q: A patient inventing new words is a feature of?

Schizophrenia. ***Schizophrenia*** - The invention of new words, known as **neologisms**, is a characteristic symptom of **thought disorder** in schizophrenia. - These words often have personal meaning to the patient but are unintelligible to others, reflecting disturbed communication. *Neurotic disorders* - These disorders, such as anxiety and phobias, primarily involve **distress and maladaptive coping mechanisms** but do not typically feature neologisms. - **Thought content** may be ruminative or anxious, but not disorganized to the extent of inventing new words. *Aphasia* - Aphasia is a **language disorder caused by brain damage** (e.g., stroke), resulting in difficulty with language production or comprehension. - While it can involve word-finding difficulties or paraphasias (word substitutions), it is distinctly different from the deliberate invention of new, non-existent words seen in psychosis. *Obsessive-Compulsive Disorder (OCD)* - OCD is characterized by **recurrent, intrusive thoughts (obsessions)** and repetitive behaviors (compulsions). - It does not involve thought disorganization or the creation of neologisms; language remains structured, though often focused on obsessive themes.

Q: The site of lesion in Korsakoff's psychosis is

Mammillary body. ***Mammillary body*** - **Korsakoff's psychosis** is a neurocognitive disorder characterized by severe **memory impairment**, confabulation, and apathy, primarily due to **thiamine deficiency**. - The disease involves damage to several brain areas, most notably the **mammillary bodies** and the dorsal medial nucleus of the thalamus, which are critical for memory formation. *Frontal lobe* - While frontal lobe dysfunction can lead to cognitive deficits, the **primary lesion** in Korsakoff's psychosis is not typically located here. - Damage to the frontal lobe is more commonly associated with executive dysfunction, personality changes, and disinhibition, rather than the profound amnesia seen in Korsakoff's. *Cingulate gyrus* - The cingulate gyrus plays a role in emotion, learning, and memory, but it is **not considered the primary site of lesion** in Korsakoff's psychosis. - Although it can be affected, lesions in the mammillary bodies are more directly linked to the characteristic memory deficits. *Corpus striatum* - The corpus striatum is involved in motor control and habit formation, and its damage is associated with movement disorders like **Parkinson's or Huntington's disease**. - This area is **not the primary site of pathology** in Korsakoff's psychosis, which is fundamentally a memory disorder.

Q: Which first-line conventional drug is commonly used in the treatment of delirium?

Haloperidol. ***Haloperidol*** - **Haloperidol** is a first-generation antipsychotic widely considered the **first-line conventional drug** for managing **agitation and psychotic symptoms** in delirium (particularly in the context of this 2015 exam). - Its efficacy in controlling these symptoms promptly, coupled with its availability in oral, intramuscular, and intravenous forms, makes it a preferred choice, especially in acute settings. - **Note:** Current evidence (post-2018) emphasizes non-pharmacological interventions first, with antipsychotics reserved for severe agitation when non-pharmacological measures fail. *Lithium carbonate* - **Lithium carbonate** is primarily used as a **mood stabilizer** for bipolar disorder, not for acute management of delirium. - It has a narrow therapeutic window and requires **careful monitoring of blood levels** to prevent toxicity, making it unsuitable for acute delirium management. *Opioids* - **Opioids** are mainly used for **pain management** and can actually **exacerbate delirium** due to their sedative and central nervous system depressant effects. - They are not indicated for treating the core symptoms of delirium, such as disorientation, fluctuating consciousness, or psychotic features. *Selective Serotonin Reuptake Inhibitors (SSRIs)* - **SSRIs** are primarily used for the treatment of **depression and anxiety disorders**, and their therapeutic effects take several weeks to manifest. - They are not effective for the immediate management of acute delirium and may even **worsen confusion or agitation** in some delirious patients.

Q: Which of the following statements about lipoma is radiologically true?

Low attenuation on CT scan. ***Low attenuation on CT scan*** - Lipomas, being composed of **fat**, appear as areas of **low attenuation** (typically -50 to -150 Hounsfield Units) on computed tomography (CT) scans. - This low attenuation is a **key diagnostic characteristic** that helps differentiate lipomas from other soft tissue masses. *Hyperechoic on ultrasound* - Lipomas typically appear **isoechoic to hypoechoic** on ultrasound, not consistently hyperechoic. - They may have a thin echogenic capsule, but the internal contents are usually similar to or less echogenic than adjacent subcutaneous fat. *Hyperintense on fat-suppressed sequences* - This is **incorrect** - lipomas show **signal dropout** (become dark/hypointense) on fat-suppressed sequences (STIR, fat-sat T1/T2). - Signal suppression on fat-saturated sequences is actually a **diagnostic feature** confirming the fatty nature of the lesion. - Note: Lipomas ARE hyperintense on standard T1-weighted imaging due to fat content. *Hyper-intense on T2-weighted MRI* - Lipomas typically show **intermediate to slightly hyperintense signal** on T2-weighted MRI, but not markedly hyperintense like fluid. - They are less bright than fluid-filled structures or highly vascular lesions on T2-weighted sequences.

Q: Investigation of choice to evaluate intracranial hemorrhage of less than 48 hours is -

CT scan. ***CT scan*** - **Non-contrast CT** is the most sensitive and rapid imaging modality for detecting acute intracranial hemorrhage, appearing as a **hyperdense** (bright) area within the brain parenchyma or subarachnoid space. - It is readily available in emergency settings and is crucial for immediate diagnosis to guide management, especially within the first **48 hours**. *MRI* - While MRI can detect hemorrhage, its sensitivity for **acute hemorrhage** (especially within the first few hours) is less than CT, and it is more time-consuming. - MRI is superior for detecting older hemorrhage or subtle lesions, but it is not the **first-line investigation** for acute bleeding. *PET* - **Positron Emission Tomography** (PET) scans are primarily used to assess metabolic activity and blood flow in the brain, often for conditions like cancer, epilepsy, or dementia. - It does not directly visualize fresh blood and therefore is not used for the diagnosis of **acute intracranial hemorrhage**. *SPECT* - **Single-Photon Emission Computed Tomography** (SPECT) is used to evaluate cerebral blood flow and neuronal activity, similar to PET but with different tracers and resolution. - It is not indicated for the rapid assessment of **acute intracranial hemorrhage** as it does not directly image blood.

Q: In a patient with a tender and rigid abdomen, what is the expected finding on X-ray?

Air under the diaphragm. ***Air under the diaphragm*** - The presence of **free air** (pneumoperitoneum) beneath the diaphragm on an upright abdominal X-ray is a classic sign of **visceral perforation**. - A **tender and rigid abdomen** (peritoneal signs) indicates irritation of the peritoneum, most commonly due to a ruptured hollow viscus. *Blood under the diaphragm* - While blood can accumulate under the diaphragm (e.g., from **trauma** or a ruptured ectopic pregnancy), it typically manifests as a **hemoperitoneum** on imaging. - Blood is **fluid** and would appear as a fluid collection, not free air, on X-ray. *Hazy lung fields* - **Hazy lung fields** suggest conditions like **pulmonary edema**, pneumonia, or acute respiratory distress syndrome (ARDS). - These findings are primarily associated with pulmonary pathology and are not directly indicative of an acute abdominal emergency like perforation. *Prominent vascular markings* - **Prominent vascular markings** often indicate increased blood flow to the lungs or **pulmonary hypertension**. - This finding is unrelated to acute abdominal pain or peritoneal irritation.

Q: What condition is best diagnosed using a Skyline view X-ray?

Patellofemoral problem. ***Patellofemoral problem*** - The **Skyline view**, also known as the **Merchant view** or tangential patella view, is specifically designed to visualize the **patellofemoral joint**. - It is crucial for assessing conditions like **patellar subluxation**, tracking disorders, and **chondromalacia patellae** by showing the articulation between the patella and the femoral trochlea. *Radioulnar problem* - Problems with the **radioulnar joint** are typically evaluated with standard **AP and lateral views of the forearm and elbow**. - The Skyline view offers no diagnostic value for the radioulnar joint as it focuses on the knee. *Tibiofibular problem* - Issues concerning the **tibiofibular joints** (proximal or distal) are best assessed using **AP and lateral views of the lower leg or ankle**, depending on the specific joint. - The Skyline view is not used to evaluate these structures. *Skull fracture* - **Skull fractures** are diagnosed using standard **skull X-rays** (e.g., AP, lateral, Towne, Caldwell views) or more commonly, a **CT scan of the head**. - The Skyline view is specific to the knee and entirely inappropriate for evaluating the skull.

Question 1

Which of the following drugs is an alpha 2 agonist?

Accepted Answer

Apraclonidine

Answer

Timolol

Answer

PG analogues

Answer

Verapamil

Question 2

Which of the following is not typically associated with dementia?

Accepted Answer

Alteration of consciousness

Answer

Reduced personal care

Answer

Loss of neurons in brain

Answer

Forgetfulness

Question 3

A patient inventing new words is a feature of?

Accepted Answer

Schizophrenia

Answer

Aphasia

Answer

Neurotic disorders

Answer

Obsessive-Compulsive Disorder (OCD)

Question 4

The site of lesion in Korsakoff's psychosis is

Accepted Answer

Mammillary body

Answer

Frontal lobe

Answer

Cingulate gyrus

Answer

Corpus striatum

Question 5

Which first-line conventional drug is commonly used in the treatment of delirium?

Accepted Answer

Haloperidol

Answer

Lithium carbonate

Answer

Opioids

Answer

Selective Serotonin Reuptake Inhibitors (SSRIs)

Question 6

What is an illusion?

Accepted Answer

Abnormal perception by a sensory misinterpretation of actual stimulus

Answer

Perception without stimuli

Answer

Fear of closed spaces

Answer

A false unshaken belief not keeping one's sociocultural background

Question 7

Which of the following statements about lipoma is radiologically true?

Accepted Answer

Low attenuation on CT scan

Answer

Hyperechoic on ultrasound

Answer

Hyperintense on fat-suppressed sequences

Answer

Hyper-intense on T2-weighted MRI

Question 8

Investigation of choice to evaluate intracranial hemorrhage of less than 48 hours is -

Accepted Answer

CT scan

Answer

MRI

Answer

PET

Answer

SPECT

Question 9

In a patient with a tender and rigid abdomen, what is the expected finding on X-ray?

Accepted Answer

Air under the diaphragm

Answer

Blood under the diaphragm

Answer

Hazy lung fields

Answer

Prominent vascular markings

Question 10

What condition is best diagnosed using a Skyline view X-ray?

Accepted Answer

Patellofemoral problem

Answer

Tibiofibular problem

Answer

Skull fracture

Answer

Radioulnar problem

NEET-PG 2015

Pharmacology

Psychiatry

Radiology