Pharmacogenomics — MCQs

Pharmacodynamics deals with:-

HLA-B*5701 is an allele associated with hypersensitivity to abacavir. Which of the following is the parent allele of HLA-B*5701?

A patient presents with painful oral ulcers and target lesions on extremities. Which drug is MOST likely to cause this condition?

Which of the following medications does not interact with warfarin?

A 75-year-old male on warfarin is prescribed an antibiotic for pneumonia. Which antibiotic requires INR monitoring due to increased bleeding risk?

Which of the following cytochromes is involved in monooxygenase mediated detoxification of drugs?

Which of the following combinations can result in severe toxicity due to inhibition of cytochrome P450 enzymes?

Perifascicular atrophy of muscle fibers is seen in?

What is the primary molecular mechanism by which UV light induces carcinogenesis?

A pathologist receives a formalin-fixed paraffin-embedded (FFPE) tissue section. Which technique is most appropriate to identify and localize specific proteins within this section in situ?