Pharmacogenomics — MCQs

A patient on warfarin has a high INR. Which drug likely caused this?

Which of the following statements represents the most clinically significant aspect of drug metabolism?

Which drug is contraindicated in G6PD deficiency?

Which of the following cytochromes is involved in monooxygenase mediated detoxification of drugs?

A patient is on warfarin therapy. All of the following drugs increase the risk of bleeding with warfarin except?

Which of the following drugs is metabolized by CYP2D6?

Which of the following combinations can result in severe toxicity due to inhibition of cytochrome P450 enzymes?

A patient with parathyroid hyperplasia, pancreatic neuroendocrine tumor, and recurrent peptic ulcer disease most commonly has mutation of which gene?

A 17-year-old boy presents with gradually progressive muscle weakness predominantly involving the proximal muscles of the lower limbs. He has difficulty climbing stairs and getting up from a squatting position. There is a significant family history and his elder brother had similar complaints and died around the age of 40 years. Based on the age of onset, pattern of inheritance, and survival, what is the most likely diagnosis?

A patient presents with ataxia, ichthyosis, retinitis pigmentosa, and cardiac conduction defects. Laboratory evaluation reveals increased phytanic acid levels. What is the most likely diagnosis?