Prostaglandins and Eicosanoids Practice Questions

Question 1

Which of the following is not a definite use for Prostaglandin E2 (PGE2)?

Accepted Answer

Keeps patency of PDA

Answer

Induces labour

Answer

Contraception

Answer

Therapeutic abortion

Question 2

What is an atypical side effect of montelukast?

Accepted Answer

Churg-Strauss syndrome

Answer

Goodpasture syndrome

Answer

Membranous glomerulonephritis

Answer

Bronchial asthma

Question 3

Zileuton is:-

Accepted Answer

5-Lipoxygenase inhibitor

Answer

Phospholipase inhibitor

Answer

Leukotriene receptor antagonist

Answer

Cyclooxygenase inhibitor

Question 4

Chemotaxis is mediated by-

Accepted Answer

Leukotriene B4 and C5a

Answer

Histamine

Answer

Leukotriene C4 and C3a

Answer

Bradykinin

Question 5

Which of the following is the MOST accurate statement regarding thromboxane A2?

Accepted Answer

Prothrombogenic

Answer

Formed by platelets

Answer

Formed from PGG2/PGH2

Answer

Vasoconstrictor

Question 6

Mechanism of action of aspirin in pain relief is:

Accepted Answer

Inhibits COX enzymes

Answer

Enhances opioid action

Answer

Activates serotonin receptors

Answer

Blocks NMDA receptors

Question 7

A newborn presents with craniofacial abnormalities, severely reduced muscle tone, and
seizures. Biochemical analysis reveals elevated very long chain fatty acids in serum. What is the
most likely underlying cause?

Accepted Answer

Peroxisomal biogenesis defect

Answer

Mitochondrial inheritance

Answer

Lysosomal storage disorder

Answer

Simultaneously activate multiple tumor suppressor genes

Question 8

Elevated serum triglyceride levels are observed in all of the following conditions EXCEPT:

Accepted Answer

Abetalipoproteinemia

Answer

Type 2 diabetes mellitus

Answer

High fructose diet

Answer

Nephrotic syndrome

Question 9

Reverse cholesterol transport is mediated by which lipoprotein?

Accepted Answer

HDL

Answer

VLDL

Answer

LDL

Answer

IDL

Question 10

Which lipoprotein has the highest concentration of endogenous triglycerides?

Accepted Answer

VLDL (Very-low-density lipoprotein)

Answer

Chylomicrons

Answer

LDL (Low-density lipoprotein)

Answer

HDL (High-density lipoprotein)

Prostaglandins and Eicosanoids — MCQs

Prostaglandins and Eicosanoids — MCQs

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