NEET-PG 2013 Practice Questions

Q: Which of the following is a stomach poison?

Paris green. ***Paris green*** * **Paris green** (copper(II) acetoarsenite) is primarily used as a **stomach poison** for insects, meaning it needs to be ingested to be effective. * It is a **highly toxic inorganic compound** that disrupts cellular respiration. * *DDT* * **DDT (dichlorodiphenyltrichloroethane)** is a **contact poison** and neurotoxin, primarily absorbed through the insect's cuticle. * It primarily affects the insects' **nervous system**, causing uncontrolled firing of neurons. * *Malathion* * **Malathion** is an **organophosphate insecticide** that acts as a **contact and stomach poison**, but its primary mode of action is through contact and fumigant effects. * It inhibits **acetylcholinesterase**, leading to paralysis and death in insects. * *Pyrethrum* * **Pyrethrum** is a natural insecticide derived from **chrysanthemum flowers** that acts primarily as a **contact poison** and repellent. * It causes **rapid knockdown** of insects by affecting their nervous system, though many insects may recover if not exposed to high enough doses.

Q: In a developing country, the prevalence of diabetes mellitus is increasing at an annual rate of 1.8%. Using epidemiological principles similar to the Rule of 70, approximately how many years will it take for the diabetes prevalence to double, and what are the primary healthcare planning implications of this growth rate?

35-46 years. ***35-46 years*** - Using the **Rule of 70**, divide 70 by the annual growth rate (1.8%): 70 / 1.8 ≈ **38.89 years**. This value falls within the 35-46 year range. - The doubling of diabetes prevalence within this timeframe necessitates significant **healthcare planning implications**, including increased demand for diagnostic services, medications, and specialized care, as well as focused preventative measures. *30-35 years* - This range is too low, as the calculated doubling time of approximately **38.89 years** is longer than this range. While close, this timeframe underestimates the actual time needed for prevalence to double. *25-30 years* - This range is significantly lower than the calculated doubling time of approximately **38.89 years**, meaning it underestimates the time required for diabetes prevalence to double by about 9-14 years. *20-25 years* - This range is far too low, as the calculated doubling time of approximately **38.89 years** is much longer. This timeframe would suggest a much higher annual growth rate than the stated 1.8%.

Q: Which vaccine is contraindicated in pregnancy?

Measles vaccine. ***Measles vaccine*** - The measles vaccine is a **live attenuated vaccine**, which carries a theoretical risk of causing infection in the fetus. - Live vaccines are generally **contraindicated during pregnancy** due to this potential risk of congenital infection. *Cholera vaccine* - The cholera vaccine is generally considered **safe during pregnancy** if indicated, especially for travel to endemic areas. - While administration in pregnancy should be based on risk-benefit, it is not consistently contraindicated like live vaccines. *Typhoid vaccine* - Both inactivated and live attenuated typhoid vaccines are available; the **inactivated (killed) vaccine** is generally preferred if vaccination is necessary during pregnancy. - The risks of the disease usually outweigh the vaccine risks, and it is not a universal contraindication. *Meningococcal vaccine* - **Meningococcal vaccines** are generally considered safe and can be administered during pregnancy if there is a significant risk of exposure or during outbreaks. - The benefits of maternal and potential fetal protection from meningococcal disease outweigh theoretical risks.

Q: Which of the following gases is a significant contributor to the greenhouse effect?

All of the options. ***All of the options*** - All listed gases (CO2, Methane, and Sulfur hexafluoride) are recognized as significant **greenhouse gases**, contributing to the **greenhouse effect** and **climate change**. - While they differ in their **global warming potential** and atmospheric lifetimes, each plays a role in trapping heat in the Earth's atmosphere. *CO2* - **Carbon dioxide** is a major greenhouse gas, primarily from the burning of **fossil fuels** and deforestation. - It is often considered the most significant contributor due to its high atmospheric concentration and long-term effects. *Methane* - **Methane** is a potent greenhouse gas, with a much higher **global warming potential** per molecule than CO2 over a shorter timescale. - Its sources include agricultural activities (livestock, rice cultivation), natural gas leaks, and landfills. *Sulfur hexafluoride* - **Sulfur hexafluoride** is a synthetic greenhouse gas with an extremely high **global warming potential** and a very long atmospheric lifetime. - Although its atmospheric concentration is lower than CO2 or methane, its potency makes it a significant contributor in specialized industrial applications.

Q: Which traditional method is considered most reliable for personal identification in forensic science?

Galton method. ***Galton method*** - The **Galton method**, which refers to **fingerprint analysis**, is considered a highly reliable traditional method for personal identification due to the uniqueness and permanence of fingerprints. - No two individuals, even identical twins, have been found to have the exact same **fingerprint patterns**, making it a robust identifier. *Gustafson's method* - **Gustafson's method** is a technique used for **age estimation based on dental changes**, not for definitive personal identification. - While it provides an estimate of age, it cannot uniquely identify an individual. *DNA profiling* - **DNA profiling** is indeed the most reliable method for personal identification in modern forensic science, but it is not considered a "traditional" method. - The question specifically asks for a **traditional method**, distinguishing it from newer genetic techniques. *Anthropometry* - **Anthropometry** involves the measurement of the **human body and its parts**, often used for classification or to establish demographic profiles. - It is not reliable for unique personal identification as many individuals share similar physical measurements.

Q: What is the time limit for exhumation in India?

No specific time limit. ***No specific time limit*** - In India, there is **no specific legal time limit** for exhumation; it is subject to the discretion of a magistrate or judicial authority. - Exhumation is ordered if there is a **reasonable suspicion or compelling grounds** to believe that an examination of the remains will provide crucial evidence for a criminal investigation. *One month* - This is **incorrect** as there is no such restrictive time frame for exhumation in Indian law. - Exhumations are ordered based on the investigative needs, not arbitrary short deadlines. *One year* - This time limit is **not stipulated** in Indian legal provisions for exhumation. - The decision to exhume is made on a case-by-case basis, considering factors like the preservation status of the body and the potential evidentiary value. *Ten years* - There is **no fixed legal period** like ten years limiting exhumations in India. - The decaying state of a body over an extended period might reduce its forensic value, but technically, exhumation can still be ordered if deemed necessary for justice.

Q: Which of the following bacteria can be identified using phage typing?

Salmonella. ***Salmonella*** - **Phage typing** is the most classical and widely used method for subtyping *Salmonella* species based on their susceptibility to specific bacteriophages. - This technique is extensively used in **epidemiological tracking** of outbreaks, particularly for *Salmonella typhi* and *S. enteritidis*, allowing differentiation of strains within the same species. - **Most commonly associated organism** with phage typing in clinical microbiology and medical education. *Streptococcus* - While phage typing was historically used for *Streptococcus pyogenes* (Group A Streptococcus), it has largely been replaced by **molecular typing methods** and is not the primary association when phage typing is mentioned. - *Streptococcus* species are typically identified through **Gram staining**, **catalase tests**, **hemolysis patterns** on blood agar, and **serological methods** (Lancefield grouping). *Shigella* - **Phage typing** is not routinely used for *Shigella* identification or subtyping in clinical practice. - **Serotyping** and **molecular methods** like pulse-field gel electrophoresis (PFGE) or whole genome sequencing are the standard approaches for *Shigella* differentiation. *Pseudomonas* - While **phage typing** has been used for *Pseudomonas aeruginosa* in research and outbreak investigations, it is not the primary or most commonly cited example of phage typing in medical education. - Routine identification relies on **culture characteristics** (pigment production, oxidase positive), **biochemical tests**, and **molecular methods**.

Q: Inclusion body containing glycogen is seen in which of the following organisms?

Chlamydia trachomatis. ***Chlamydia trachomatis*** - This species is known to form **intracytoplasmic inclusion bodies** that contain **glycogen**. - The presence of this glycogen allows these inclusions to be stained by **iodine**, aiding in laboratory identification. *Chlamydia pneumoniae* - Inclusion bodies of *Chlamydia pneumoniae* are typically **round or pear-shaped** and **do not contain glycogen**. - They are often **vacuolated** and stain poorly with iodine, unlike those of *C. trachomatis*. *Chlamydia psittaci* - The inclusion bodies of *Chlamydia psittaci* are usually **dense and pleiomorphic**, but they **do not contain glycogen**. - They tend to be **larger** and are often found near the host cell nucleus. *None of the options* - This option is incorrect because *Chlamydia trachomatis* specifically forms **glycogen-containing inclusion bodies**. - The presence of glycogen within inclusions is a key distinguishing feature of this species.

Q: All of the following are adverse effects of nicotinic acid except:

Pancreatitis. ***Pancreatitis*** - **Pancreatitis** is not a commonly reported adverse effect of nicotinic acid (niacin) therapy. - While other gastrointestinal side effects like nausea and vomiting can occur, pancreatic inflammation is not characteristic. *Vasodilation* - **Cutaneous flushing** and **vasodilation** are very common adverse effects of nicotinic acid, mediated by prostaglandin release. - This effect can cause a sensation of warmth, redness, and itching, especially at the start of therapy. *Liver dysfunction* - **Liver dysfunction**, including elevated liver enzymes and rare cases of **hepatotoxicity**, can occur with high doses of nicotinic acid. - Regular monitoring of liver function tests is recommended for patients on niacin therapy. *Hyperpigmentation* - **Hyperpigmentation**, particularly **acanthosis nigricans**, is a known cutaneous side effect of nicotinic acid. - This typically presents as dark, velvety patches on the skin, especially in skin fold areas.

Q: Ranibizumab is a monoclonal antibody against?

VEGF. ***VEGF*** - **Ranibizumab** is a **monoclonal antibody** specifically designed to inhibit **vascular endothelial growth factor A (VEGF-A)**. - By binding to VEGF-A, ranibizumab prevents its interaction with receptors on endothelial cells, thereby inhibiting **angiogenesis** and reducing vascular permeability, which is crucial in treating conditions like **wet age-related macular degeneration (AMD)** and **diabetic macular edema**. *Interleukin-6* - **Interleukin-6 (IL-6)** is a **pro-inflammatory cytokine** involved in various autoimmune and inflammatory diseases. - Monoclonal antibodies targeting IL-6, such as **tocilizumab**, are used in conditions like **rheumatoid arthritis** and **cytokine release syndrome**, not for ocular neovascularization. *Cluster of Differentiation 20* - **Cluster of Differentiation 20 (CD20)** is a protein found on the surface of **B lymphocytes**. - Monoclonal antibodies against CD20, like **rituximab**, are used in the treatment of **B-cell lymphomas**, **leukemia**, and certain **autoimmune diseases**, not for conditions requiring anti-VEGF therapy. *Epidermal Growth Factor Receptor* - The **epidermal growth factor receptor (EGFR)** is a **tyrosine kinase receptor** involved in cell growth and proliferation. - Monoclonal antibodies targeting EGFR, such as **cetuximab** and **panitumumab**, are used in the treatment of various **cancers**, particularly **colorectal cancer** and **head and neck cancer**.

Question 1

Which of the following is a stomach poison?

Accepted Answer

Paris green

Answer

DDT

Answer

Malathion

Answer

Pyrethrum

Question 2

In a developing country, the prevalence of diabetes mellitus is increasing at an annual rate of 1.8%. Using epidemiological principles similar to the Rule of 70, approximately how many years will it take for the diabetes prevalence to double, and what are the primary healthcare planning implications of this growth rate?

Accepted Answer

35-46 years

Answer

30-35 years

Answer

25-30 years

Answer

20-25 years

Question 3

Which vaccine is contraindicated in pregnancy?

Accepted Answer

Measles vaccine

Answer

Cholera vaccine

Answer

Typhoid vaccine

Answer

Meningococcal vaccine

Question 4

Which of the following gases is a significant contributor to the greenhouse effect?

Accepted Answer

All of the options

Answer

CO2

Answer

Methane

Answer

Sulfur hexafluoride

Question 5

Which traditional method is considered most reliable for personal identification in forensic science?

Accepted Answer

Galton method

Answer

Gustafson's method

Answer

Anthropometry

Answer

DNA profiling

Question 6

What is the time limit for exhumation in India?

Accepted Answer

No specific time limit

Answer

One year

Answer

Ten years

Answer

One month

Question 7

Which of the following bacteria can be identified using phage typing?

Accepted Answer

Salmonella

Answer

Streptococcus

Answer

Shigella

Answer

Pseudomonas

Question 8

Inclusion body containing glycogen is seen in which of the following organisms?

Accepted Answer

Chlamydia trachomatis

Answer

Chlamydia pneumoniae

Answer

Chlamydia psittaci

Answer

None of the options

Question 9

All of the following are adverse effects of nicotinic acid except:

Accepted Answer

Pancreatitis

Answer

Liver dysfunction

Answer

Vasodilation

Answer

Hyperpigmentation

Question 10

Ranibizumab is a monoclonal antibody against?

Accepted Answer

VEGF

Answer

Interleukin-6

Answer

Cluster of Differentiation 20

Answer

Epidermal Growth Factor Receptor

NEET-PG 2013

Community Medicine

Forensic Medicine

Microbiology

Pharmacology