Cholinergic/Adrenergic drugs — Flashcards

Flashcard 301: Is bupropion use associated with sexual dysfunction? _____

Answer: No

Flashcard 302: Phenylephrine may be used as a _____ for ocular procedures

Answer: mydriatic

Flashcard 303: Acetylcholinesterase inhibitors may be used to treat urinary _____

Answer: retention

Flashcard 304: What demographic is associated with organophosphate poisoning? _____

Answer: Farmers

Flashcard 305: Guanfacine differs from Clonidine in that is it _____ by cytochrome p450

Answer: metabolized (metabolized or not metabolized?)

Flashcard 306: Is phenoxybenzamine (alpha-blocker) selective or non-selective?

Answer: Non-selective

Flashcard 307: Which adrenergic receptor is sympatholytic? _____

Answer: $\alpha_2$ (Alpha-2) receptor

Extra: $\alpha_2$ receptors are presynaptic G_i-coupled receptors that provide negative feedback, inhibiting further norepinephrine release.

Flashcard 308: Cholinomimetics cause _____ of bronchial smooth muscle, which may exacerbate asthma or COPD

Answer: contraction

Flashcard 309: Food poisoning via _____ toxin inhibits the release of acetylcholine, affecting both nicotinic and muscarinic transmission.

Answer: Botulinum (produced by *Clostridium botulinum*)

Extra: Botulinum toxin cleaves SNARE proteins (e.g., synaptobrevin), preventing the fusion of acetylcholine (ACh) vesicles with the presynaptic membrane. This inhibits ACh release at all cholinergic junctions, including the neuromuscular junction (nicotinic) and parasympathetic postganglionic terminals (muscarinic).

Flashcard 310: What adverse effect may pseudoephedrine and phenylephrine have on blood pressure? _____

Answer: Increased BP (Hypertension)