HIV — Flashcards

Flashcard 11: HIV and HTLV-1 are both _____

Answer: retroviruses

Extra:  https://onlinemeded.org?ref=anki 

Flashcard 12: Infected CD4+ T cells (and macrophages, dendritic cells) are killed by _____ in HIV

Answer: CD8+ T-cells

Extra:  https://onlinemeded.org/spa/infectious-disease/hiv/acquire?ref=anki 

Flashcard 13: HIV infects CD4+ helper T-cells, macrophages, and _____

Answer: dendritic cells

Extra:   Watch Maraviroc, fusion inhibitors, integrase inhibitors [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-antimicrobials/videos/medical-pharmacology-antimicrobials-antivirals-hiv-maraviroc-fusion-inhibitors-integrase-inhibitors?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/infectious-disease?ref=anki 

Flashcard 14: _____ are diploid single-stranded RNA viruses

Answer: Retroviruses (e.g. HIV)

Flashcard 15: Individuals with _____-zygous CCR5 allele mutations are resistant to HIV infection

Answer: homo

Extra: Homozygous CCR5-Δ32 mutation: resistance to HIV infection. Heterozygous CCR5-Δ32 mutation: delayed disease progression.

Flashcard 16: HIV RNA is transcribed to dsDNA by _____

Answer: HIV reverse transcriptase

Extra:    https://onlinemeded.org/spa/infectious-disease?ref=anki 

Flashcard 17: Which HIV gene encodes for the gp120 and gp41 surface glycoproteins? _____

Answer: env

Extra:    https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki 

Flashcard 18: Which viral gene in HIV codes for the p17 matrix protein? _____

Answer: gag

Extra:    https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki 

Flashcard 19: Which envelope protein on HIV functions to allow HIV fusion and entry into host cells? _____

Answer: gp41

Extra:    https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki 

Flashcard 20: Nocardia causes _____ infections in the immuno-compromised

Answer: pulmonary

Extra:  https://onlinemeded.org/spa/infectious-disease?ref=anki